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Ester hydrolysis by a histidine-containing cavitein.

Hui Yang, John C Sherman

Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC, Canada V6T 1Z1.

Bioorganic & medicinal chemistry letters 2013 Mar 15


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    We have used a template-assembled synthetic protein (TASP) to investigate catalytic function in ester hydrolysis. A histidine-containing cavitein has been found to catalyze ester hydrolysis with a rate increase of 18 times that of background. Copyright © 2013 Elsevier Ltd. All rights reserved.

    Citation

    Hui Yang, John C Sherman. Ester hydrolysis by a histidine-containing cavitein. Bioorganic & medicinal chemistry letters. 2013 Mar 15;23(6):1752-3

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    PMID: 23414804

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