Topical cyclosporine A for postoperative photorefractive keratectomy and laser in situ keratomileusis.

David Hessert, David Tanzer, Tyson Brunstetter, Sandor Kaupp, Donna Murdoch, Myah Mirzaoff

Naval Hospital Bremerton, Bremerton, Washington 98337, USA. david.hessert@med.navy.mil

Journal of cataract and refractive surgery 2013 Apr

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To compare the stability and predictability of the refractive outcomes in eyes treated with photorefractive keratectomy (PRK) or laser in situ keratomileusis (LASIK) with and without postoperative use of topical cyclosporine A emulsion. Naval Medical Center San Diego Refractive Surgery Center, San Diego, California, USA. Randomized clinical trial. Patients had PRK or LASIK and were randomized, pairwise, to a standard postoperative treatment regimen with or without the addition of topical cyclosporine A 0.05% emulsion twice daily for 3 months postoperatively. Visual acuity, mesopic contrast acuity, refractions, and ocular symptoms were assessed through the 3-month examination. Tear-film samples (cytokines and chemokines) were analyzed preoperatively and 1 week and 1 and 3 months postoperatively. The PRK group comprised 70 patients and the LASIK group, 54 patients. The addition of topical cyclosporine A twice a day after PRK or LASIK did not confer special benefits in terms of achievement of target refraction, final uncorrected distance visual acuity (UDVA), or rate of visual recovery (all P>.05, multivariate analysis of variance [MANOVA]). There was no significant difference in tear-film composition based on measurement of matrix metalloproteinase-9, interleukin (IL)-6, or IL-8 recovery (all P>.05, MANOVA). The addition of topical cyclosporine A twice daily for 3 months after PRK or LASIK did not provide a significant benefit in the rate of visual recovery, final UDVA, or patient symptoms, nor did it significantly change measured inflammatory mediators (cytokines) present in the tear film. Published by Elsevier Inc.

Citation

David Hessert, David Tanzer, Tyson Brunstetter, Sandor Kaupp, Donna Murdoch, Myah Mirzaoff. Topical cyclosporine A for postoperative photorefractive keratectomy and laser in situ keratomileusis. Journal of cataract and refractive surgery. 2013 Apr;39(4):539-47