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Cerium has been widely used as fertilizer and feed additives in agriculture, but it might finally impair human health by food chain accumulation with its dosage increased in environmental and crops samples. To resolve the conflict, we investigated the effects of Ce(III) on isolated rice mitochondrial permeability transition (MPT) by examining mitochondrial swelling, transmembrane potential, membrane fluidity with spectroscopy, and observing the mitochondrial ultrastructure, meanwhile, the interaction site(s) and mechanism between Ce(III) and mitochondria were also studied. The results showed that the low level of Ce(III) had little effect on rice MPT, however, the higher level of Ce(III) could induce rice MPT, and the thiol (-SH) groups of membrane proteins (defined as "S" site) matched by Ce(III)-triggered rice MPT pore opening.


Cai-Fen Xia, Jie Zhao, Jian-Cheng Jin, Lian Yuan, Xin-You Chen, Wu Peng, Feng-Lei Jiang, Cai-Qin Qin, Jie Dai, Yi Liu. Ce(III)-induced rice mitochondrial permeability transition investigated by spectroscopic and microscopic studies. Biological trace element research. 2013 May;152(2):284-91

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PMID: 23417494

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