Selective separation and enrichment of glibenclamide in health foods using surface molecularly imprinted polymers prepared via dendritic grafting of magnetic nanoparticles.

In this paper, the novel surface molecularly imprinted polymers based on dendritic-grafting magnetic nanoparticles were developed to enrich and separate glibenclamide in health foods. The density functional theory method was used to give theoretical directions to the synthesis of molecularly imprinted polymers. The polymers were prepared by using magnetic nanoparticles as supporting materials, methacrylic acid as the functional monomer, and ethylene glycol dimethacrylate as the cross-linker. The characteristics of magnetic nanoparticles and polymers were measured by transmission electron microscope and SEM, respectively. The enriching ability of molecularly imprinted polymers was measured by Freundlich Isotherm. The molecularly imprinted polymers were used as dispersive SPE materials to enrich, separate, and detect glibenclamide in health foods by HPLC. The average recoveries of glibenclamide in spiked health foods were 81.46-93.53% with the RSD < 4.07%. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Ruoyu Wang, Yang Wang, Cheng Xue, Tingting Wen, Jinhua Wu, Junli Hong, Xuemin Zhou. Selective separation and enrichment of glibenclamide in health foods using surface molecularly imprinted polymers prepared via dendritic grafting of magnetic nanoparticles. Journal of separation science. 2013 Mar;36(6):1015-21

Mesh Tags

Substances

PMID: 23418142

search → result