Long-term adherence to follow-up after treatment of cervical intraepithelial neoplasia: nationwide population-based study.

To measure adherence to annual follow-up among women treated for cervical intraepithelial neoplasia. Prospective, population-based, register study. Denmark, 1996-2007. All women treated for cervical intraepithelial neoplasia with conization. Treated women were routinely recommended to have follow-up with annual smears for at least 5 years. Using individually linked nationwide register data on conizations and follow-up tests (smears and biopsies), we calculated the cumulative proportion of treated women undergoing the recommended follow-up. We measured this cumulative proportion conservatively in 15-month intervals for 5 years. Adherence to annual follow-up among 45,984 treated women decreased gradually. In total, 90% of these women obtained at least one smear in the first post-treatment year, but only 40% obtained the recommended tests for 5 years. Five-year adherence was substantially better outside the capital area, for example, the odds ratio for women from Jutland compared with women from the capital area was 1.70 (95% confidence interval 1.60-1.82). Adherence to follow-up after conization was poor in Denmark. Our findings suggest that because of this poor adherence, recommendations for long-term annual follow-up after treatment of cervical intraepithelial neoplasia may not be highly effective. Shorter follow-up schedules using highly sensitive tests appear attractive. © 2013 The Authors Acta Obstetricia et Gynecologica Scandinavica © 2013 Nordic Federation of Societies of Obstetrics and Gynecology.

Citation

Sidsel S Barken, Elsebeth Lynge, Erik S Andersen, Matejka Rebolj. Long-term adherence to follow-up after treatment of cervical intraepithelial neoplasia: nationwide population-based study. Acta obstetricia et gynecologica Scandinavica. 2013 Jul;92(7):852-7

Mesh Tags

PMID: 23418941

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