Mast cells as novel mediators of reproductive processes.

The relationship between mast cells (MCs) and pregnancy is a controversially discussed topic. The presence and quantitative distribution of MCs in the reproductive tract was confirmed in different species. A phase-dependent oscillation of MCs during the hormonal regulated estrous cycle was suggested and on this basis, MCs were assumed to play a positive role in implantation because of their ability to secrete histamine. At later pregnancy stages, they were proposed to have rather a negative role, as their exacerbated activation is associated with pre-term delivery. The present review is intended to provide an overview about uterine MCs that bring to light their unexpected relevance for reproductive processes.

Citation

Katja Woidacki, Federico Jensen, Ana C Zenclussen. Mast cells as novel mediators of reproductive processes. Frontiers in immunology. 2013;4:29

PMID: 23419968

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