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A biomimetic quantum dot synthesis-based strategy for ultrasensitive label-free detection of protease activities is reported. A dithiol peptide substrate can be activated by the protease through cleavage to form monothiol peptides, which then triggers QD growth and generates a photoluminescence signal readout. As low as 0.8 nM trypsin can be detected directly in buffer and serum and 4 pM trypsin can be detected via trypsinogen amplification with high signal to background ratios. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Xuewen He, Nan Ma. Biomimetic synthesis of fluorogenic quantum dots for ultrasensitive label-free detection of protease activities. Small (Weinheim an der Bergstrasse, Germany). 2013 Aug 12;9(15):2527-31

PMID: 23420767

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