Antithymocyte globulin/antilymphocyte globulin plus kidney-nourishing Chinese medicinal: effect on severe aplastic anemia.

To explore the effect of antithymocyte globulin (ATG)/antilymphocyte globulin (ALG) plus kidney-nourishing Chinese medicinal (KNCM) on severe aplastic anemia (SAA). Twenty-five subjects of severe aplastic anemia were treated with ATG/ALD plus KNCM between 1992 and 2009, and the clinical data before and after treatment were collected and analyzed. Of the 25 patients, 9 were nearly cured, 6 were improved, 5 were in remission, and 5 failed. The overall effective rate was 80.0%. The 3-year, 5-year, 10-year, 15-year survival rate were respectively 98.6%, 97.3%, 97.3%, 67.5%, and median survival time was 180 months. Compared to the conditions before administering the medication of ATG/ ALG plus KNCM, after 2 weeks, reticulocyte was first improved (P = 0.001); one month later, followed by palette (P = 0.037); two months later, by neutrophil cell in peripheral blood (P = 0.001); three months later, then by the hemoglobin (P = 0.012). By conducting 1-year follow-up, 1 case of complication--paroxysmal nocturnal hemoglobinuria (PNH) was identified and the patient still alive today. ATG/ALG plus KNCM had better effect on SAA and could improve patients' survival rate.

Citation

Xudong Tang, Feng Liu, Liu Li, Chi Liu, Shanshan Zhang, Haiyan Xiao, Chunmei Zheng, Shu Xu, Rou Ma. Antithymocyte globulin/antilymphocyte globulin plus kidney-nourishing Chinese medicinal: effect on severe aplastic anemia. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine. 2012 Dec;32(4):604-8

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PMID: 23427396

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