Palladium-catalyzed decarboxylative allylation and benzylation of N-alloc and N-Cbz indoles.

A set of general methods for the palladium-catalyzed decarboxylative C3-allylation and C3-benzylation of indoles, starting from the corresponding N-alloc and N-Cbz indoles, respectively, is reported. This chemistry provides ready access to a wide range of functionalized indolenines in good to excellent yields. A tandem process, wherein the palladium catalyzed allylation chemistry is coupled with a Mizoroki-Heck reaction, offers a simple route to cinnamylated products.

Citation

Thomas D Montgomery, Ye Zhu, Natsuko Kagawa, Viresh H Rawal. Palladium-catalyzed decarboxylative allylation and benzylation of N-alloc and N-Cbz indoles. Organic letters. 2013 Mar 01;15(5):1140-3

Mesh Tags

Substances

PMID: 23427905

search → result