Dapsone-induced decrease in the HbA(1c) level may cause artefacts in diabetic control].

Siv Elisabeth Lajlev, Søren Andreas Ladefoged, Kjeld Hermansen

Medicinsk Endokrinologisk Afdeling, Aarhus Universitetshospital, Denmark. siv@lajlev.dk

Ugeskrift for laeger 2013 Feb 18

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Glycated haemoglobin (HbA(1c)) level is used to monitor glycaemic control in diabetic patients, and has recently been included as a diagnostic factor for type 2 diabetes mellitus (DM). A 50-year-old male with well-controlled type 1 DM, Mb Addison and coeliac disease was diagnosed with dermatitis herpetiformis and treated with dapsone. Subsequently, the patient presented a pronounced drop in HbA(1c) levels without changes in blood glucose levels. S-fructosamine values were in agreement with the previous stable HbA(1c) values. Blood analyses showed inappropriately low HbA(1c) values due to mild haemolysis and shortening of erythrocyte lifetime without anaemia.

Citation

Siv Elisabeth Lajlev, Søren Andreas Ladefoged, Kjeld Hermansen. Dapsone-induced decrease in the HbA(1c) level may cause artefacts in diabetic control]. Ugeskrift for laeger. 2013 Feb 18;175(8):505-6