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Imaging molecularly defined regions of chromatin in single living cells during transcriptional activation has the potential to provide new insight into gene regulatory mechanisms. Here, we describe a method for isolating cell lines with multi-copy arrays of reporter transgenes, which can be used for real-time high-resolution imaging of transcriptional activation dynamics in single cells.


Ilona U Rafalska-Metcalf, Susan M Janicki. Preparation of cell lines for single-cell analysis of transcriptional activation dynamics. Methods in molecular biology (Clifton, N.J.). 2013;977:249-58

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PMID: 23436368

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