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    Although we have convincing evidence that attention to auditory stimuli modulates neuronal responses at or before the level of primary auditory cortex (A1), the underlying physiological mechanisms are unknown. We found that attending to rhythmic auditory streams resulted in the entrainment of ongoing oscillatory activity reflecting rhythmic excitability fluctuations in A1. Strikingly, although the rhythm of the entrained oscillations in A1 neuronal ensembles reflected the temporal structure of the attended stream, the phase depended on the attended frequency content. Counter-phase entrainment across differently tuned A1 regions resulted in both the amplification and sharpening of responses at attended time points, in essence acting as a spectrotemporal filter mechanism. Our data suggest that selective attention generates a dynamically evolving model of attended auditory stimulus streams in the form of modulatory subthreshold oscillations across tonotopically organized neuronal ensembles in A1 that enhances the representation of attended stimuli. Copyright © 2013 Elsevier Inc. All rights reserved.


    Peter Lakatos, Gabriella Musacchia, Monica N O'Connel, Arnaud Y Falchier, Daniel C Javitt, Charles E Schroeder. The spectrotemporal filter mechanism of auditory selective attention. Neuron. 2013 Feb 20;77(4):750-61

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    PMID: 23439126

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