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We report the in vitro selection of a single-stranded 72-nucleotide DNA enzyme (deoxyribozyme) that catalyzes a Friedel-Crafts reaction between an indole and acyl imidazole in good yield and in aqueous solvent. Appreciable Friedel-Crafts product requires addition of copper nitrate and the deoxyribozyme. We observe deoxyribozyme-mediated bond formation for both in cis and in trans Friedel-Crafts reactions.


Utpal Mohan, Ritwik Burai, Brian R McNaughton. In vitro evolution of a Friedel-Crafts deoxyribozyme. Organic & biomolecular chemistry. 2013 Apr 14;11(14):2241-4

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PMID: 23443910

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