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In vitro evolution of a Friedel-Crafts deoxyribozyme.
Utpal Mohan, Ritwik Burai, Brian R McNaughton
Department of Chemistry, Colorado State University, 200 West Lake Street, Fort Collins, CO, USA.
Organic & biomolecular chemistry 2013 Apr 14Sizes of these terms reflect their relevance to your search.
We report the in vitro selection of a single-stranded 72-nucleotide DNA enzyme (deoxyribozyme) that catalyzes a Friedel-Crafts reaction between an indole and acyl imidazole in good yield and in aqueous solvent. Appreciable Friedel-Crafts product requires addition of copper nitrate and the deoxyribozyme. We observe deoxyribozyme-mediated bond formation for both in cis and in trans Friedel-Crafts reactions.
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Utpal Mohan, Ritwik Burai, Brian R McNaughton. In vitro evolution of a Friedel-Crafts deoxyribozyme. Organic & biomolecular chemistry. 2013 Apr 14;11(14):2241-4
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PMID: 23443910
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