Preparation and evaluation of sustained release calcium alginate beads and matrix tablets of acetazolamide.

M Barzegar-Jalali, J Hanaee, Y Omidi, S Ghanbarzadeh, S Ziaee, R Bairami-Atashgah, K Adibkia

Biotechnology Research Center Tabriz University of Medical Science, Tabriz, Iran.

Drug research 2013 Feb

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The aim of this study was to develop sustained release dosage forms of acetazolamide (ACZ) preparing its calcium alginate beads and matrix tablets. ACZ was incorporated into calcium alginate beads using microencapsulation method. Two methods were applied to prolong ACZ release rate. In the first method, the drug was incorporated into calcium alginate beads either alone or with various polymers in internal phase. The second method involved the preparation of matrix tablet from the beads benefiting direct compression method with or without various polymers in external phase. The release rate of these prepared formulations and an innovator's sustained-release capsule (Diamox®) were assessed. In-vitro dissolution studies revealed that the matrix tablets prepared by the second method containing NaCMC could sustain ACZ release properly and the drug released until 9 h. It was also found that several parameters such as concentration of sodium alginate, calcium chloride and ACZ; type and concentration of polymers; syringe needle size as well as distance between needle tip and surface of the calcium chloride could affect the properties of beads, matrix tablets and subsequently release profile. Preparation of polymer free beads, incorporation of polymers in internal phase of the beads and direct compression of the beads did not give sustained release property. Whereas, incorporation of NaCMC in the external phase of the beads in matrix tablets or in combination with alginate powder in directly compressed conventional tablets could produce dosage form with sustained release property similar to reference formulation. © Georg Thieme Verlag KG Stuttgart · New York.

Citation

M Barzegar-Jalali, J Hanaee, Y Omidi, S Ghanbarzadeh, S Ziaee, R Bairami-Atashgah, K Adibkia. Preparation and evaluation of sustained release calcium alginate beads and matrix tablets of acetazolamide. Drug research. 2013 Feb;63(2):60-4