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A 34-year-old man was admitted to our hospital with diabetic ketoacidosis due to fulminant type 1 diabetes. The patient's pancreatic exocrine and endocrine functions were as follows: the bentiromide (PABA) test value on day 14 was 33.9%, thus indicating exocrine dysfunction. One year and a half later, the PABA test value had improved to 71.0%. On the other hand, the serum C-peptide level after meal ingestion was under the detection limit. The mechanisms underlying pancreatic exocrine abnormalities seem to be different from those underlying accelerated pancreatic beta-cell failure in patients with fulminant type 1 diabetes.


Hajime M Koyano, Takao Matsumoto. Recovery from exocrine pancreatic insufficiency in a patient with fulminant type 1 diabetes. Internal medicine (Tokyo, Japan). 2013;52(5):573-5

PMID: 23448767

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