Effects of low-dose dopamine on urine output in normotensive very low birth weight neonates.

J L Crouchley, P B Smith, C M Cotten, C D Hornik, R N Goldberg, J W Foreman, J L Wynn

Journal of perinatology : official journal of the California Perinatal Association 2013 Aug

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To determine the effects of low-dose dopamine on urine output (UOP) in very low birth weight premature neonates. Retrospective cohort study of all low-dose (3-5 μg kg(-1) per min) dopamine infusions >24-h duration in neonates 1500 g and 32 weeks gestation from August 2009 through September 2011. Linear regression was used to estimate the impact of covariates on UOP. We identified 91 episodes of low-dose dopamine use in 65 neonates. Increased UOP occurred in 64% of episodes. Low-dose dopamine use was associated with a 0.6 ml kg(-1) h(-1) increase in UOP (P<0.001) and a 1.3 ml kg(-1)h(-1) increase when baseline UOP was <1.5 ml kg(-1) h(-1) (P<0.001). The improvement remained statistically significant after controlling for medications (diuretics and hydrocortisone) and fluid intake. Low-dose dopamine use was associated with increased UOP in very low birth weight neonates.

Citation

J L Crouchley, P B Smith, C M Cotten, C D Hornik, R N Goldberg, J W Foreman, J L Wynn. Effects of low-dose dopamine on urine output in normotensive very low birth weight neonates. Journal of perinatology : official journal of the California Perinatal Association. 2013 Aug;33(8):619-21