A two-dimensional proteome map of the aflatoxigenic fungus Aspergillus flavus.

Olga Pechanova, Tibor Pechan, Jose M Rodriguez, W Paul Williams, Ashli E Brown

Mississippi State Chemical Laboratory, Mississippi State University, Mississippi State, MS, USA.

Proteomics 2013 May

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The filamentous fungus Aspergillus flavus is an opportunistic soil-borne pathogen that produces aflatoxins, the most potent naturally occurring carcinogenic compounds known. This work represents the first gel-based profiling analysis of A. flavus proteome and establishes a 2D proteome map. Using 2DE and MALDI-TOF-MS/MS, we identified 538 mycelial proteins of the aflatoxigenic strain NRRL 3357, the majority of which were functionally annotated as related to various cellular metabolic and biosynthetic processes. Additionally, a few enzymes from the aflatoxin synthesis pathway were also identified. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Olga Pechanova, Tibor Pechan, Jose M Rodriguez, W Paul Williams, Ashli E Brown. A two-dimensional proteome map of the aflatoxigenic fungus Aspergillus flavus. Proteomics. 2013 May;13(9):1513-8

PMID: 23457007

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