Three 2-(methysulfanyl)nicotinamides.

Ligia R Gomes, John Nicolson Low, James L Wardell, Alessandra C Pinheiro, Thais C N de Mendonça, Marcus V N de Souza

REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, 687, P-4169-007 Porto, Portugal.

Acta crystallographica. Section C, Crystal structure communications 2013 Mar

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The molecular conformations of three N-alkyl-2-(methylsulfanyl)nicotinamide derivatives, namely N-cyclohexyl-2-(methylsulfanyl)nicotinamide, C13H18N2OS, (I), N-isopropyl-2-(methylsulfanyl)nicotinamide, C10H14N2OS, (II), in which there are two molecules in the asymmetric unit which were chosen to form a hydrogen-bonded pair, and N-(2-hydroxyethyl)-2-(methylsulfanyl)nicotinamide dihydrate, C9H12N2O2S·2H2O, (III), are compared with those of four unsubstituted N-alkylnicotinamide compounds. The substituted compounds show a higher degree of torsion of the pyridine ring with respect to the amide group than do the unsubstituted compounds, with dihedral angles in the range 40-60° for the former and 20-35° for the latter. In (I) and (II), the supramolecular structure is defined by amide-N to carbonyl-O chains. In (III), the nicotinamide molecules are linked by hydrogen bonds to two water molecules resulting in two linked chains of rings which form the three-dimensional network.

Citation

Ligia R Gomes, John Nicolson Low, James L Wardell, Alessandra C Pinheiro, Thais C N de Mendonça, Marcus V N de Souza. Three 2-(methysulfanyl)nicotinamides. Acta crystallographica. Section C, Crystal structure communications. 2013 Mar;69(Pt 3):293-8