Effects of strontium ranelate on mononuclear leukocyte culture].

I a Khlusov, A I Vengerovskiĭ, K A Nechaev, M V Dvornichenko, I V Kulagina, T V Saprina

Eksperimental'naia i klinicheskaia farmakologiia 2013

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Strontium ranelate (SR) effect on the functional parameters of human blood mononuclear leukocytes culture has been investigated. SR in concentrations of 2.9, 29, and 290 mg/ml produces a dose-dependent decrease in the activity of alkaline phosphatase and the content of calcium and potassium ions in supernatants. In concentrations of 2.9 and 29 mg/ml, SR decreases, while in a concentration of 290 mg/ml it increases the intercellular phosphate ion content. Fibroblast- and osteoblast-like cells, which are capable of regulating mineral compound of intercellular liquid, are SR cellular targets in human blood mononuclear leukocytes culture.

Citation

I a Khlusov, A I Vengerovskiĭ, K A Nechaev, M V Dvornichenko, I V Kulagina, T V Saprina. Effects of strontium ranelate on mononuclear leukocyte culture]. Eksperimental'naia i klinicheskaia farmakologiia. 2013;76(1):35-8