Soluble tag-assisted peptide head-to-tail cyclization: total synthesis of mahafacyclin B.

Yuko Fujita, Shuji Fujita, Yohei Okada, Kazuhiro Chiba

Department of Applied Biological Science, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.

Organic letters 2013 Mar 15

filter terms:

A soluble tag-assisted liquid-phase method was successfully applied to peptide head-to-tail cyclization, leading to the total synthesis of antimalarial cyclic heptapeptide, mahafacyclin B (1). The cyclization was carried out in the liquid phase with the tag remaining, which allowed rapid reaction workup and product isolation.

Citation

Yuko Fujita, Shuji Fujita, Yohei Okada, Kazuhiro Chiba. Soluble tag-assisted peptide head-to-tail cyclization: total synthesis of mahafacyclin B. Organic letters. 2013 Mar 15;15(6):1155-7