Broadening of a THz pulse as a measure of the porosity of pharmaceutical tablets.

K-E Peiponen, P Silfsten, J Pajander, J Ketolainen

Department of Physics and Mathematics, University of Eastern Finland, PO Box 111, FI-80101 Joensuu, Finland. kai.peiponen@uef.fi.

International journal of pharmaceutics 2013 Apr 15

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THz pulse time delay was measured from ethylcellulose tablets having nominal porosities 13%, 22% and 30%. It is suggested that the observed pulse broadening of sample THz pulse is due to scattering and dispersion of the THz wave in a porous tablet. A parameter related to the pulse broadening is suggested as a sensitive measure for the porosity and porosity change of the tablet. Copyright © 2013 Elsevier B.V. All rights reserved.

Citation

K-E Peiponen, P Silfsten, J Pajander, J Ketolainen. Broadening of a THz pulse as a measure of the porosity of pharmaceutical tablets. International journal of pharmaceutics. 2013 Apr 15;447(1-2):7-11