Wen-Xuan Wang, Juan Xiong, Yu Tang, Jing-Jing Zhu, Ming Li, Yun Zhao, Guo-Xun Yang, Gang Xia, Jin-Feng Hu
Department of Natural Products Chemistry, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, People's Republic of China.
Phytochemistry 2013 MayThe roots of the medicinal ornamental plant Clerodendrum trichotomum yielded a series of rearranged abietane diterpenoids, including three 17(15→16)-abeo-abietane (1-3) and three 17(15→16),18(4→3)-diabeo-abietane (4-6) derivatives. Their structures were elucidated by means of spectroscopic methods. The absolute configuration of (10R,16R)-12,16-epoxy-11,14,17-trihydroxy-6-methoxy-17(15→16)-abieta-5,8,11,13-tetraene-7-one (1) was deduced by a combination of single crystal X-ray diffraction analysis and the observed Cotton effects in its circular dichroism (CD) spectrum. All isolates were tested for their cytotoxicities against five human cancer cell lines (BGC-823, Huh-7, KB, KE-97, and Jurkat). Among them, compounds 4, 6, 9, 10, 12, and 14, each possessing a common 17(15→16),18(4→3)-diabeo-abietane framework, were found to have remarkable cytotoxic effects with IC50 values ranging from 0.83 to 50.99 μM. Copyright © 2013 Elsevier Ltd. All rights reserved.
Wen-Xuan Wang, Juan Xiong, Yu Tang, Jing-Jing Zhu, Ming Li, Yun Zhao, Guo-Xun Yang, Gang Xia, Jin-Feng Hu. Rearranged abietane diterpenoids from the roots of Clerodendrum trichotomum and their cytotoxicities against human tumor cells. Phytochemistry. 2013 May;89:89-95
PMID: 23462587
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