Expanding roles for the evolutionarily conserved Dmrt sex transcriptional regulators during embryogenesis.

Eric J Bellefroid, Lucas Leclère, Amandine Saulnier, Marc Keruzore, Maria Sirakov, Michel Vervoort, Sarah De Clercq

Cellular and molecular life sciences : CMLS 2013 Oct

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Dmrt genes encode a large family of transcription factors characterized by the presence of a DM domain, an unusual zinc finger DNA binding domain. While Dmrt genes are well known for their important role in sexual development in arthropodes, nematodes and vertebrates, several new findings indicate emerging functions of this gene family in other developmental processes. Here, we provide an overview of the evolution, structure and mechanisms of action of Dmrt genes. We summarize recent findings on their function in sexual regulation and discuss more extensively the role played by these proteins in somitogenesis and neural development.

Citation

Eric J Bellefroid, Lucas Leclère, Amandine Saulnier, Marc Keruzore, Maria Sirakov, Michel Vervoort, Sarah De Clercq. Expanding roles for the evolutionarily conserved Dmrt sex transcriptional regulators during embryogenesis. Cellular and molecular life sciences : CMLS. 2013 Oct;70(20):3829-45