Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

The first copper-catalyzed N-arylation of 2-imidazolines is described. The reaction affords compounds with desirable lead-like characteristics in high yield with practical simplicity under inexpensive, "ligand-free" conditions. The cross coupling was successful with electron-rich and electron-poor aromatic iodides. Substrates bearing halides, esters, nitriles, and free hydroxyls are well tolerated, providing reactive handles for further functionalization, as are pyridines. In addition, the regioselective N-arylation of a 4-substituted imidazoline is reported.

Citation

Owen A Davis, Matthew Hughes, James A Bull. Copper-catalyzed N-arylation of 2-imidazolines with aryl iodides. The Journal of organic chemistry. 2013 Apr 5;78(7):3470-5

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 23464665

View Full Text