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This review summarizes our research into the synthesis and structure-activity relationships of epolactaene, neoechinulin A, plakevulin A, pseudodeflectusin and ustusorane C. These natural products are attractive in view of their apoptosis-inducing activity, cytoprotective activity against peroxynitrite, inhibitory activity against DNA polymerases, and cytotoxicity in cancer cells.


Kouji Kuramochi. Synthetic and structure-activity relationship studies on bioactive natural products. Bioscience, biotechnology, and biochemistry. 2013;77(3):446-54

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PMID: 23470748

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