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Lactoferrin (LF) is a multifunctional glycoprotein found in mammalian milk. We have shown in a previous clinical study that enteric-coated bovine LF tablets decreased visceral fat accumulation. To address the underlying mechanism, we conducted in vitro studies and revealed the anti-adipogenic action of LF in pre-adipocytes. The aim of this study was to assess whether LF could increase the lipolytic activity in mature adipocytes. Pre-adipocytes were prepared from rat mesenteric fat and differentiated into mature adipocytes for assays of lipolysis. The addition of LF significantly increased the glycerol concentration in the medium in a dose-dependent manner, whereas pepsin-degraded LF did not. A DNA microarray analysis demonstrated that LF decreased the expression of perilipin and affected the cAMP pathway. These findings are supported by the results of quantitative RT-PCR of perilipin and assays of cAMP. These data collectively indicate that visceral fat reduction by LF may result from the promotion of lipolysis and the additional anti-adipogenic activity of LF.


Tomoji Ono, Chikako Fujisaki, Yasuharu Ishihara, Keiko Ikoma, Satoru Morishita, Michiaki Murakoshi, Keikichi Sugiyama, Hisanori Kato, Kazuo Miyashita, Toshihide Yoshida, Hoyoku Nishino. Potent lipolytic activity of lactoferrin in mature adipocytes. Bioscience, biotechnology, and biochemistry. 2013;77(3):566-71

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PMID: 23470763

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