Application of in situ-generated Rh-bound trimethylenemethane variants to the synthesis of 3,4-fused pyrroles.

Erica E Schultz, Richmond Sarpong

Department of Chemistry, University of California, Berkeley, California 94720, USA.

Journal of the American Chemical Society 2013 Mar 27

filter terms:

Rh-bound trimethylenemethane variants generated from the interaction of a Rh-carbenoid with an allene have been applied to the synthesis of substituted 3,4-fused pyrroles. The pyrrole products are useful starting points for the syntheses of various dipyrromethene ligands. Furthermore, the methodology has been applied to a synthesis of the natural product cycloprodigiosin, which demonstrates antitumor and immunosuppressor activity.

Citation

Erica E Schultz, Richmond Sarpong. Application of in situ-generated Rh-bound trimethylenemethane variants to the synthesis of 3,4-fused pyrroles. Journal of the American Chemical Society. 2013 Mar 27;135(12):4696-9