Bone scintigraphic findings of hypophosphatemic osteomalacia associated with adefovir therapy: involvement of lower extremity skeletons.

Do-Hoon Kim, Sang-Woo Lee, Young Oh Kweon, Jaetae Lee, Byeong-Cheol Ahn

Department of Nuclear Medicine, Kyungpook National University School of Medicine and Hospital, Daegu, Republic of Korea.

Clinical nuclear medicine 2013 May

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Occurrence of hypophosphatemic osteomalacia (HO) induced by administration of low-dose adefovir therapy is rare, and bone scintigraphy of the disease has rarely been reported. We report on bone scintigraphic findings in patients with HO. Multiple uptakes in ribs, spines, and lower extremities, suggesting multiple fractures, were observed on bone scintigraphy. Patients were diagnosed as HO associated with adefovir therapy. Owing to the same predilection sites, multiple uptakes on the axial skeleton can cause confusion with malignant metastatic disease; however, involvement of lower extremity skeletons can provide a scintigraphic clue for use in differentiation of HO from malignant osseous metastasis.

Citation

Do-Hoon Kim, Sang-Woo Lee, Young Oh Kweon, Jaetae Lee, Byeong-Cheol Ahn. Bone scintigraphic findings of hypophosphatemic osteomalacia associated with adefovir therapy: involvement of lower extremity skeletons. Clinical nuclear medicine. 2013 May;38(5):378-80