Intestinal perforation in very-low-birth-weight infants with necrotizing enterocolitis.

To identify risk factors for intestinal perforation in very-low-birth-weight (VLBW) infants with necrotizing enterocolitis (NEC). Retrospective case-control study over a 10-year period, using univariate and multivariate logistic regression analyses to compare all VLBW infants treated for perforated NEC, with two age and weight-matched groups: infants with non-perforated NEC and infants without NEC. Twenty infants with perforated NEC were matched to 20 infants with non-perforated NEC and 38 infants without NEC. Infants with perforated NEC were younger (p<0.01) and had higher rates of abdominal distention, metabolic acidosis, hyperglycemia and elevated liver enzymes (p<0.05). On logistic regression analysis, abdominal distention was associated with an increased risk of intestinal perforation (OR 39.8, 95% CI 2.71-585) and late onset of NEC (one-day increments) was associated with a decreased risk (OR 0.93, 95% CI 0.87-1.0). Identification of abdominal distention at an early age in VLBW infants should lead to increased vigilance for signs of perforated NEC and may enable early intervention. Copyright © 2013 Elsevier Inc. All rights reserved.

Citation

Nehama Linder, Naama Hammel, Adriana Hernandez, Elena Fridman, Elena Dlugy, Tina Herscovici, Gil Klinger. Intestinal perforation in very-low-birth-weight infants with necrotizing enterocolitis. Journal of pediatric surgery. 2013 Mar;48(3):562-7

Mesh Tags

PMID: 23480913

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