Hydroxyproline content and fibrogenesis in mouse liver and lungs during the early stages of BCG granulomatosis.

V A Shkurupiy, L B Kim, I K Nikonova, O V Potapova, L A Cherdantseva, T V Sharkova

Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.

Bulletin of experimental biology and medicine 2013 Jan

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In generalized BCG granulomatosis, fibrosis starts early (on day 3) and not only around the granulomas, but also in the organs. The severity of organ fibrosis is apparently determined by the concentration of granulomas, in particular their macrophages inducing proliferation of fibroblasts in organs and granulomas as well as activation of fibrogenesis. On day 30 after infection, the degree of fibrosis in the lungs was by 6 times higher than in the liver. The increase in hydroxyproline concentration in organs in early period of infection was determined by acute stress, while on day 30 it resulted from its enhanced synthesis by granuloma fibroblasts and resident fibroblasts in organs.

Citation

V A Shkurupiy, L B Kim, I K Nikonova, O V Potapova, L A Cherdantseva, T V Sharkova. Hydroxyproline content and fibrogenesis in mouse liver and lungs during the early stages of BCG granulomatosis. Bulletin of experimental biology and medicine. 2013 Jan;154(3):299-302