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Recurrent respiratory papillomatosis (RRP) describes an infection of the upper aerodigestive tract by the human papilloma virus most commonly affecting the larynx with rare lung involvement in 1%-2% of affected patients. We describe an unusual case of a 28-year-old male patient with a longstanding history of RRP where a whole-body PET/CT obtained for disease staging revealed multiple cavitary pulmonary nodules in addition to the more typical tracheobronchial papillomas. In the case described herein, we report heterogeneous uptake of 18F-FDG among these RRP lesions, suggesting significant unexpected variability in the underlying metabolic behavior of these lesions.


John-Paul J Yu, Ramon F Barajas, Dare Olorunsola, Leo P Sugrue, Miguel Hernandez-Pampaloni. Heterogeneous 18F-FDG uptake in recurrent respiratory papillomatosis. Clinical nuclear medicine. 2013 May;38(5):387-9

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PMID: 23486321

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