Novel indole alkaloids from Nauclea latifolia and their renin-inhibitory activities.

Anthony A Agomuoh, Athar Ata, Chibuike C Udenigwe, Rotimi E Aluko, Iwu Irenus

Department of Biology, Richardson College for the Environmental and Science Complex, The University of Winnipeg, 599 Portage Ave., Winnipeg, MB, Canada R3B 2G3.

Chemistry & biodiversity 2013 Mar

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Chemical studies on the crude MeOH extract of stems and barks of Nauclea latifolia resulted in the isolation of five new indole alkaloids, latifoliamides A-E (1-5, resp.), along with one known alkaloid, angustoline (6). The structures of these compounds were elucidated by means of extensive NMR spectral studies. Compound 1 has a 20-ethylidenetetrahydrofuran ring incorporated in its structure and represents the first example of this class of indole alkaloids. All of the isolates exhibited moderate in vitro renin inhibitory activities. Copyright © 2013 Verlag Helvetica Chimica Acta AG, Zürich.

Citation

Anthony A Agomuoh, Athar Ata, Chibuike C Udenigwe, Rotimi E Aluko, Iwu Irenus. Novel indole alkaloids from Nauclea latifolia and their renin-inhibitory activities. Chemistry & biodiversity. 2013 Mar;10(3):401-10