Second-coordination-sphere effects increase the catalytic efficiency of an extended model for Fe(III)M(II) purple acid phosphatases.

Bernardo de Souza, Gabriel L Kreft, Tiago Bortolotto, Hernán Terenzi, Adailton J Bortoluzzi, Eduardo E Castellano, Rosely A Peralta, Josiel B Domingos, Ademir Neves

Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina 88040-900, Brazil.

Inorganic chemistry 2013 Apr 1

filter terms:

Herein we describe the synthesis of a new heterodinuclear Fe(III)Cu(II) model complex for the active site of purple acid phosphatases and its binding to a polyamine chain, a model for the amino acid residues around the active site. The properties of these systems and their catalytic activity in the hydrolysis of bis(2,4-dinitrophenyl)phosphate are compared, and conclusions regarding the effects of the second coordination sphere are drawn. The positive effect of the polymeric chain on DNA hydrolysis is also described and discussed.

Citation

Bernardo de Souza, Gabriel L Kreft, Tiago Bortolotto, Hernán Terenzi, Adailton J Bortoluzzi, Eduardo E Castellano, Rosely A Peralta, Josiel B Domingos, Ademir Neves. Second-coordination-sphere effects increase the catalytic efficiency of an extended model for Fe(III)M(II) purple acid phosphatases. Inorganic chemistry. 2013 Apr 1;52(7):3594-6