Role of formyl peptide receptor 2 on the serum amyloid A-induced macrophage foam cell formation.

Ha Young Lee, Sang Doo Kim, Suk-Hwan Baek, Joon Hyuk Choi, Yoe-Sik Bae

Department of Biological Science, Sungkyunkwan University, Suwon 440-746, South Korea. hayoung@skku.edu

Biochemical and biophysical research communications 2013 Apr 5

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Recently we demonstrated that SAA induces macrophage foam cell formation. In this study we show that SAA-induced foam cell formation is inhibited by formyl peptide receptor 2 (FPR2) antagonist WRW(4), as well as by FPR2-targeted siRNA knockdown. SAA-stimulated LOX1 expression was also mediated by FPR2. We also found that SAA-stimulated foam cell formation and LOX1 expression was pertussis toxin-insensitive. In addition, FPR2 is upregulated in peripheral blood mononuclear cells from patients with atherosclerosis. Our findings therefore suggest that SAA stimulates foam cell formation via FPR2 signaling and LOX1 induction, and thus likely contributes to atherogenesis. Copyright © 2013 Elsevier Inc. All rights reserved.

Citation

Ha Young Lee, Sang Doo Kim, Suk-Hwan Baek, Joon Hyuk Choi, Yoe-Sik Bae. Role of formyl peptide receptor 2 on the serum amyloid A-induced macrophage foam cell formation. Biochemical and biophysical research communications. 2013 Apr 5;433(2):255-9