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Catastrophic antiphospholipid antibody syndrome (CAPS) is a rare syndrome associated with multiorgan failure that carries a high mortality rate. It has been defined previously by the presence of autoantibodies in a patient with acute multiorgan failure as a result of small vessel occlusion by multiple thrombi. We report a patient who meets all criteria of CAPS except for persistent seronegativity.


Amanda Shreders, Michael Bar. A case of seronegative catastrophic antiphospholipid antibody syndrome. Connecticut medicine. 2013 Feb;77(2):81-3

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PMID: 23513635

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