Zephgrabetaine: a new betaine-type amaryllidaceae alkaloid from Zephyranthes grandiflora.

Deepali Katoch, Dharmesh Kumar, Upendra Sharma, Neeraj Kumar, Yogendra S Padwad, Brij Lal, Bikram Singh

Natural Plant Products Division, CSIR - Institute of Himalayan Bioresource Technology, Post Box No. 6, Palampur 176 061 (HP), India.

Natural product communications 2013 Feb

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Zephgrabetaine (1), a new betaine type Amaryllidaceae alkaloid, along with seven known alkaloids, lycorine, galanthine, lycoramine, hamayne, haemanthamine, tortuosine, and ungeremine were isolated from the bulbs of Zephyranthes grandiflora and their structures elucidated by spectroscopic data analysis. The isolated alkaloids were tested for in vitro cytotoxic activities against two cell lines, C-6 (rat glioma cells) and CHO-K1 (Chinese hamster ovary cells). A dose dependent cytotoxic effect was exhibited by all the alkaloids on these two cancer cell lines with prominent activity of lycorine and haemanthamine.

Citation

Deepali Katoch, Dharmesh Kumar, Upendra Sharma, Neeraj Kumar, Yogendra S Padwad, Brij Lal, Bikram Singh. Zephgrabetaine: a new betaine-type amaryllidaceae alkaloid from Zephyranthes grandiflora. Natural product communications. 2013 Feb;8(2):161-4