Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues.

Habibullah Peerzada, Jay A Gandhi, Allan J Guimaraes, Joshua D Nosanchuk, Luis R Martinez

Immunobiology 2013 Aug

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Methamphetamine (METH) is a potent and highly addictive central nervous system (CNS) stimulant. Additionally, METH adversely impacts immunological responses, which might contribute to the higher rate and more rapid progression of certain infections in drug abusers. However no studies have shown the impact of METH on inflammation within specific organs, cellular participation and cytokine production. Using a murine model of METH administration, we demonstrated that METH modifies, with variable degrees, leukocyte recruitment and alters cellular mediators in the lungs, liver, spleen and kidneys of mice. Our findings demonstrate the pleotropic effects of METH on the immune response within diverse tissues. These alterations have profound implications on tissue homeostasis and the capacity of the host to respond to diverse insults, including invading pathogens. Copyright © 2013 Elsevier GmbH. All rights reserved.

Citation

Habibullah Peerzada, Jay A Gandhi, Allan J Guimaraes, Joshua D Nosanchuk, Luis R Martinez. Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues. Immunobiology. 2013 Aug;218(8):1063-8