Haemoglobin SD disease--rare case of jaundice.

A 15 years old Muslim female presented with moderate anaemia, mild jaundice and hepatosplenomegaly with no history of blood transfusion in the past. Routine examination was suggestive of haemolytic jaundice. High pressure liquid chromatography (HPLC) electrophoresis of the patient's blood showed haemoglobin (Hb) SD disease. As it is a double heterozygous disease, family screening was done. It showed that the father was sickle cell trait. Mother was Hb D trait. Both the brothers were sickle cell trait and the only sister was normal. Hb SD disease is a very rare variety of haemoglobinopathy and the case is presented here due to its rarity.

Citation

Udas Chandra Ghosh, Krishna Sen, Atindra Narayan, Kajal Krishna Banik, Pradip Kumar Saha. Haemoglobin SD disease--rare case of jaundice. Journal of the Indian Medical Association. 2012 Jul;110(7):501-2

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PMID: 23520682

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