HO-1 as modulator of the innate immune response in pregnancy.

Kristina Kahlo, Sara Fill Malfertheiner, Tanja Ignatov, Federico Jensen, Serban-Dan Costa, Anne Schumacher, Ana C Zenclussen

Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.

American journal of reproductive immunology (New York, N.Y. : 1989) 2013 Jul

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The immune modulatory effect of heme oxygenase-1 (HO-1) is well documented in studies about sepsis and transplantation. This work evaluates the influence of HO-1 on the innate immune response during pregnancy. Human first-trimester trophoblasts derived from normal pregnancies or spontaneous abortions were analyzed for their basal HO-1, BCL-associated athanogene-1 (Bag-1), and cytokine production before and after LPS treatment. In vivo, pregnant Hmox1+/+ and Hmox1+/- female mice were treated with LPS, and the production of Bag-1 was evaluated. Human trophoblasts up-regulated the expression of both HO-1 and pro-inflammatory cytokines after LPS treatment, whereas the basal level of HO-1 was higher in normal pregnancies. In vivo, HO-1 deficiency provoked diminished Bag-1 level upon LPS treatment. HO-1 deficiency causes an inflammatory immune reaction and diminished expression of protective molecules in trophoblasts. Thus, HO-1 emerges as one important modulator of innate immune responses in pregnancy. © 2013 John Wiley & Sons Ltd.

Citation

Kristina Kahlo, Sara Fill Malfertheiner, Tanja Ignatov, Federico Jensen, Serban-Dan Costa, Anne Schumacher, Ana C Zenclussen. HO-1 as modulator of the innate immune response in pregnancy. American journal of reproductive immunology (New York, N.Y. : 1989). 2013 Jul;70(1):24-30