The Trypanosoma brucei telomerase RNA (TER) homologue binds core proteins of the C/D snoRNA family.

Sachin Kumar Gupta, Liat Kolet, Tirza Doniger, Viplov Kumar Biswas, Ron Unger, Yehuda Tzfati, Shulamit Michaeli

The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.

FEBS letters 2013 May 2

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Trypanosome protozoan parasites are the causative agents of devastating diseases. Trypanosome telomeres grow in an uncontrolled manner and the variant surface glycoprotein (VSG) genes are located in subtelomeric domains. The gene encoding telomerase reverse transcriptase (TERT) was identified and in this study, we describe the Trypanosoma brucei telomerase RNA (TER). TER RNA is bound by the core proteins of the C/D small nucleolar RNA (snoRNA) family and associates with the methyltransferase-associated protein (MTAP), whose homologue binds to mammalian TER. Silencing of TbTER resulted in telomere shortening. This is the first report of a TER that binds the C/D snoRNA core proteins. Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Citation

Sachin Kumar Gupta, Liat Kolet, Tirza Doniger, Viplov Kumar Biswas, Ron Unger, Yehuda Tzfati, Shulamit Michaeli. The Trypanosoma brucei telomerase RNA (TER) homologue binds core proteins of the C/D snoRNA family. FEBS letters. 2013 May 2;587(9):1399-404