A click-activated fluorescent probe for selective detection of hydrazoic acid and its application in biological imaging.

Yi Zhou, Yue-Wei Yao, Qi Qi, Yuan Fang, Jing-Yun Li, Cheng Yao

State Key Laboratory of Materials-Oriented Chemical Engineering and College of Science, Nanjing University of Technology, Nanjing 210009, PR China.

Chemical communications (Cambridge, England) 2013 Jul 7

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Here we present a new approach to aqueous hydrazoic acid detection through the synthesis and evaluation of an alkyne-based fluorescent probe, which could be applied in the monitoring of hydrazoic acid in both living Hela cells and larval zebrafish. This probe can also serve as an early warning automaton which would alert when both azide and protons exist over the threshold value.

Citation

Yi Zhou, Yue-Wei Yao, Qi Qi, Yuan Fang, Jing-Yun Li, Cheng Yao. A click-activated fluorescent probe for selective detection of hydrazoic acid and its application in biological imaging. Chemical communications (Cambridge, England). 2013 Jul 7;49(53):5924-6

PMID: 23525157

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