Correlation Engine 2.0
Clear Search sequence regions


  • adult (1)
  • birth weight (1)
  • child (1)
  • child preschool (1)
  • children (9)
  • cholesterol (2)
  • cohort (1)
  • female (1)
  • humans (1)
  • igf i (1)
  • IGF II (1)
  • insulin (5)
  • lipids (1)
  • mass (1)
  • mothers (10)
  • pregnancy (1)
  • somatomedins (2)
  • weight (1)
  • young adult (1)
  • Sizes of these terms reflect their relevance to your search.

    Maternal age at childbirth continues to increase worldwide. We aimed to assess whether increasing maternal age is associated with changes in childhood height, body composition, and metabolism. 277 healthy pre-pubertal children, born 37-41 weeks gestation were studied. Assessments included: height and weight corrected for parental measurements, DEXA-derived body composition, fasting lipids, glucose, insulin, and hormonal profiles. Subjects were separated according to maternal age at childbirth: <30, 30-35, and >35 years. Our cohort consisted of 126 girls and 151 boys, aged 7.4 ± 2.2 years (range 3-10); maternal age at childbirth was 33.3 ± 4.7 years (range 19-44). Children of mothers aged >35 and 30-35 years at childbirth were taller than children of mothers aged <30 years by 0.26 (p = 0.002) and 0.23 (p = 0.042) SDS, respectively. There was a reduction in childhood BMISDS with increasing maternal age at childbirth, and children of mothers aged >35 years at childbirth were 0.61 SDS slimmer than those of mothers <30 years (p = 0.049). Children of mothers aged 30-35 (p = 0.022) and >35 (p = 0.036) years at childbirth had abdominal adiposity reduced by 10% and 13%, respectively, compared to those in the <30 group. Children of mothers aged 30-35 years at childbirth displayed a 19% increase in IGF-I concentrations compared to offspring in <30 group (p = 0.042). Conversely, IGF-II concentrations were lower among the children born to mothers aged 30-35 (6.5%; p = 0.004) and >35 (8.1%; p = 0.005) compared to those of mothers aged <30 years. Girls of mothers aged 30-35 years at childbirth also displayed improved HOMA-IR insulin sensitivity (p = 0.010) compared to girls born to mothers aged <30 years. Increasing maternal age at childbirth is associated with a more favourable phenotype (taller stature and reduced abdominal fat) in their children, as well as improved insulin sensitivity in girls.

    Citation

    Tim Savage, José G B Derraik, Harriet L Miles, Fran Mouat, Paul L Hofman, Wayne S Cutfield. Increasing maternal age is associated with taller stature and reduced abdominal fat in their children. PloS one. 2013;8(3):e58869

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 23527040

    View Full Text