Controlling the rate of coiled coil driven membrane fusion.

Tingting Zheng, Jens Voskuhl, Frank Versluis, Harshal R Zope, Itsuro Tomatsu, Hana Robson Marsden, Alexander Kros

Soft Matter Chemistry, Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

Chemical communications (Cambridge, England) 2013 May 7

filter terms:

Sets of complementary lipidated coiled-coil forming peptides that fuse membrane fusion have been designed. The influence of the coiled-coil motif on the rate of liposome fusion was studied, by varying the number of heptad repeats. We found that an increased coiled-coil stability of complementary peptides translates into increased rates of membrane fusion of liposomes.

Citation

Tingting Zheng, Jens Voskuhl, Frank Versluis, Harshal R Zope, Itsuro Tomatsu, Hana Robson Marsden, Alexander Kros. Controlling the rate of coiled coil driven membrane fusion. Chemical communications (Cambridge, England). 2013 May 7;49(35):3649-51