Development and validation of a method for the analysis of paroxetine HCl by circular dichroism.

Zenaide S do Monte, Clécio S Ramos

Department of Molecular Sciences, Rural Federal University of Pernambuco, Recife-Pe, Brazil, CP 52.171-030.

Chirality 2013 Apr

filter terms:

A simple, rapid, and sensitive method for the analysis of paroxetine, in tablets as well as the pure drug, by circular dichroism is described. The method was validated for repeatability, linearity, limit of detection, limit of quantification, and recovery according to the International Conference on Harmonization guidelines. Excellent results were obtained, within the globally accepted validation reference values, particularly taking into account the low concentration levels investigated. This is the first report of the quantitation of paroxetine, a chiral drug, without previous separation of the analyte. Additionally, the solid state CD spectrum of PXT was obtained. Copyright © 2013 Wiley Periodicals, Inc.

Citation

Zenaide S do Monte, Clécio S Ramos. Development and validation of a method for the analysis of paroxetine HCl by circular dichroism. Chirality. 2013 Apr;25(4):211-4