Service de néphrologie et d'hypertension, Département de médecine interne, CHUV, 1011 Lausanne. olivier.phan@chuv.ch
Revue médicale suisse 2013 Feb 27The mechanisms of vascular calcifications in chronic renal failure are complex. Apart for clotting factors, vitamin K-dependent proteins include matrix Gla protein. Glutamic acid residues in matrix Gla protein are carboxylated by vitamin K-dependent gamma-carboxylase, which enables it to inhibit calcification. The purpose of this review is to discuss available evidence implicating vitamin K as a modifiable risk factor in the pathogenesis of vascular calcification in renal diseases.
O Phan, M Burnier. Vascular calcifications and vitamin K deficiency: a modifiable risk factor in chronic kidney disease]. Revue médicale suisse. 2013 Feb 27;9(375):451-2, 454-5
PMID: 23539811
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