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The mechanisms of vascular calcifications in chronic renal failure are complex. Apart for clotting factors, vitamin K-dependent proteins include matrix Gla protein. Glutamic acid residues in matrix Gla protein are carboxylated by vitamin K-dependent gamma-carboxylase, which enables it to inhibit calcification. The purpose of this review is to discuss available evidence implicating vitamin K as a modifiable risk factor in the pathogenesis of vascular calcification in renal diseases.

Citation

O Phan, M Burnier. Vascular calcifications and vitamin K deficiency: a modifiable risk factor in chronic kidney disease]. Revue médicale suisse. 2013 Feb 27;9(375):451-2, 454-5

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PMID: 23539811

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