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Taste-independent nutrient selection is mediated by a brain-specific Na+ /solute co-transporter in Drosophila.
Monica Dus, Minrong Ai, Greg S B Suh
Nature neuroscience 2013 May
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Animals can determine the nutritional value of sugar without the influence of taste. We examined a Drosophila mutant that is insensitive to the nutritional value of sugars, responding only to the concentration (that is, sweetness). The affected gene encodes a sodium/solute co-transporter-like protein, designated SLC5A11 (or cupcake), which is structurally similar to mammalian sodium/glucose co-transporters that transport sugar across the intestinal and renal lumen. However, SLC5A11 was prominently expressed in 10-13 pairs of R4 neurons of the ellipsoid body in the brain and functioned in these neurons for selecting appropriate foods.
Citation
Monica Dus, Minrong Ai, Greg S B Suh.
Taste-independent nutrient selection is mediated by a brain-specific Na+ /solute co-transporter in Drosophila.
Nature neuroscience.
2013 May;16(5):526-8
Mesh Tags
Analysis of Variance
Animals
Animals, Genetically Modified
Base Sequence
Brain
CD8 Antigens
Choice Behavior
Dose-Response Relationship, Drug
Drosophila
Drosophila Proteins
Food Deprivation
Food Preferences
Gene Expression Regulation
Glucose
Glycogen
Green Fluorescent Proteins
Hemolymph
Humans
Mutation
Neurons
RNA Interference
Receptors, Cell Surface
Sodium-Glucose Transport Proteins
Taste
Transcription Factors
Substances
CD8 Antigens
Drosophila Proteins
GAL4 protein, Drosophila
Receptors, Cell Surface
SLC5A11 protein, Drosophila
Sodium-Glucose Transport Proteins
Transcription Factors
gustatory receptor, Drosophila
Green Fluorescent Proteins
Glycogen
Glucose
PMID: 23542692
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