Aspects of determining the molecular weight of cyclodextrin polymers and oligomers by static light scattering.

István Puskás, Alexandra Szemjonov, Éva Fenyvesi, Milo Malanga, Lajos Szente

CycloLab Research and Development Laboratory Ltd., 1097 Budapest, Illatos út 7, Hungary. puskas@cyclolab.hu

Carbohydrate polymers 2013 Apr 15

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Methodic issues affecting the use of static light scattering to determine the average molecular weight of cyclodextrin poly- and oligomers are discussed. The critical features which enable accurate measurement such as aggregation behavior and segment-segment interaction are elucidated. Static light scattering data supported with globule size and aggregate state analysis (as determined by dynamic light scattering) allowed the aggregate-free state of the samples to be justified and the ideal globular conformation of the macromolecules to be corroborated. These molecular characteristics were demonstrated for uncharged, charged and fluorescent randomly crosslinked water soluble cyclodextrin poly- and oligomers. Copyright © 2013 Elsevier Ltd. All rights reserved.

Citation

István Puskás, Alexandra Szemjonov, Éva Fenyvesi, Milo Malanga, Lajos Szente. Aspects of determining the molecular weight of cyclodextrin polymers and oligomers by static light scattering. Carbohydrate polymers. 2013 Apr 15;94(1):124-8