Department of Laboratory Medicine and Pathology, University of Alberta Hospital, Edmonton, AB, Canada.
Methods in molecular biology (Clifton, N.J.) 2013Although clinical requests for D-dimer are generally in the minority of assays in the routine clinical laboratory, they are an important aspect-especially if the laboratory supports an active emergency room and hematology service. Throughout the literature, D-dimer assays have been used for many purposes in the research setting; however it is generally the negative predictive value of the assay that is the most common piece of information being utilized from the standpoint of a clinician. Research or clinical needs will dictate the type of assay required-a qualitative, semiquantitative, or quantitative D-dimer assay may be appropriate for a particular purpose. Commonalities and differences between these assay types are outlined here, as well as universal concerns regarding standardization of D-dimer assay results.
Linda J Stang. D-dimer and fibrinogen/fibrin degradation products. Methods in molecular biology (Clifton, N.J.). 2013;992:415-27
PMID: 23546734
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