A convenient approach to the synthesis of the phosphoramidite non-nucleotide monomers for the preparation of functionalized oligonucleotide derivatives].

M S Kopriushkin, D V Pyshnyĭ

Bioorganicheskaia khimiia 2012 Nov-Dec

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A simple approach to the synthesis of phosphoramidite synthons for non-nucleotide inserts using 4-(2-(4,4'-dimethoxytrityloxy)ethyl)morpholine-2,3-dione as a key precursor is suggested. Using the method developed various inserts have been introduced into oligonucleotides to obtain intercalator-containing (acridine) as well as branched oligonucleotides.

Citation

M S Kopriushkin, D V Pyshnyĭ. A convenient approach to the synthesis of the phosphoramidite non-nucleotide monomers for the preparation of functionalized oligonucleotide derivatives]. Bioorganicheskaia khimiia. 2012 Nov-Dec;38(6):745-9