HIV-1 Vpu does not degrade interferon regulatory factor 3.

It has been reported that HIV-1 Vpu mediates the degradation of interferon regulatory factor 3 (IRF-3) to avoid innate immune sensing. Here, we show that Vpu does not deplete IRF-3 from transfected cell lines or HIV-1-infected primary cells. Furthermore, the Vpu-dependent suppression of beta interferon expression described in previous studies could be ascribed to inhibition of NF-κB activation. Thus, Vpu suppresses innate immune activation through inhibition of NF-κB rather than degradation of IRF-3.

Citation

Dominik Hotter, Frank Kirchhoff, Daniel Sauter. HIV-1 Vpu does not degrade interferon regulatory factor 3. Journal of virology. 2013 Jun;87(12):7160-5

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PMID: 23552418

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